According to the Ghost Hunters website, John Wilkes Booth and the Samuel Mudd house will be featured on the show on Wednesday evening, August 26, 2009. The show airs at 9:00 p.m. EDT (8:00 p.m. CDT) on the Syfy channel.
John Wilkes Booth stopped at Dr. Mudd's house to have his injured leg treated while he was attempting to escape after the assassination on President Abraham Lincoln.
Here's a link to the Ghost Hunters website. If the link doesn't work, try copying it and pasting it into your browser window and hitting enter.